Hibernians defeated Tarxien Rainbows 4-1 to make sure to start the third round with at least a seven-point lead over their nearest rivals.
Ten-man Naxxar Lions found no difficulty in beating Zebbug Rangers 4-0. Balzan suffered a shock 1-2 defeat to Pieta Hotspurs while Sliema Wanderers defeated Mosta 2-1.